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Evasion of adaptive immunity by HIV through the action of host APOBEC3G/F enzymes
APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral proteins, entr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594601/ https://www.ncbi.nlm.nih.gov/pubmed/28893290 http://dx.doi.org/10.1186/s12981-017-0173-8 |