Sulforaphane Induced Apoptosis via Promotion of Mitochondrial Fusion and ERK1/2-Mediated 26S Proteasome Degradation of Novel Pro-survival Bim and Upregulation of Bax in Human Non-Small Cell Lung Cancer Cells

Previous studies in our laboratory showed that sulforaphane (SFN) induced apoptosis by sustained activation of extracellular regulated protein kinases 1/2 (ERK1/2). However, the underlying mechanisms associated with SFN-induced apoptosis and downstream cascades which are modulated by ERK1/2 were not...

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Detalles Bibliográficos
Autores principales: Geng, Yang, Zhou, Yan, Wu, Sai, Hu, Yabin, Lin, Kai, Wang, Yalin, Zheng, Zhongnan, Wu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595075/
https://www.ncbi.nlm.nih.gov/pubmed/28900483
http://dx.doi.org/10.7150/jca.19383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595075/
https://www.ncbi.nlm.nih.gov/pubmed/28900483
http://dx.doi.org/10.7150/jca.19383

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