Depolarization of the conductance-voltage relationship in the Na(V)1.5 mutant, E1784K, is due to altered fast inactivation

E1784K is the most common mixed long QT syndrome/Brugada syndrome mutant in the cardiac voltage-gated sodium channel Na(V)1.5. E1784K shifts the midpoint of the channel conductance-voltage relationship to more depolarized membrane potentials and accelerates the rate of channel fast inactivation. The...

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Detalles Bibliográficos
Autores principales: Peters, Colin H., Yu, Alec, Zhu, Wandi, Silva, Jonathan R., Ruben, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595308/
https://www.ncbi.nlm.nih.gov/pubmed/28898267
http://dx.doi.org/10.1371/journal.pone.0184605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595308/
https://www.ncbi.nlm.nih.gov/pubmed/28898267
http://dx.doi.org/10.1371/journal.pone.0184605

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