TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses

Toll-like receptor (TLR)-mediated signaling are critical for host defense against pathogen invasion. However, excessive responses would cause harmful damages to the host. Here we show that deficiency of the E3 ubiquitin ligase TRIM32 increases poly(I:C)- and LPS-induced transcription of downstream g...

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Detalles Bibliográficos
Autores principales: Yang, Qing, Liu, Tian-Tian, Lin, Heng, Zhang, Man, Wei, Jin, Luo, Wei-Wei, Hu, Yun-Hong, Zhong, Bo, Hu, Ming-Ming, Shu, Hong-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595311/
https://www.ncbi.nlm.nih.gov/pubmed/28898289
http://dx.doi.org/10.1371/journal.ppat.1006600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595311/
https://www.ncbi.nlm.nih.gov/pubmed/28898289
http://dx.doi.org/10.1371/journal.ppat.1006600

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