Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair

Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhib...

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Detalles Bibliográficos
Autores principales: Zhang, Shuang, Yeap, Xin-Yi, DeBerge, Matthew, Naresh, Nivedita K., Wang, Kevin, Jiang, Zhengxin, Wilcox, Jane E., White, Steven M., Morrow, John P., Burridge, Paul W., Procissi, Daniel, Scott, Evan A., Frazier, William, Thorp, Edward B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
MINI-FOCUS: INFLAMMATION IN CARDIAC INJURY
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595371/
https://www.ncbi.nlm.nih.gov/pubmed/28920097
http://dx.doi.org/10.1016/j.jacbts.2017.03.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595371/
https://www.ncbi.nlm.nih.gov/pubmed/28920097
http://dx.doi.org/10.1016/j.jacbts.2017.03.013

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