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Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers

Reduced neurogenesis in the aging mammalian hippocampus has been linked to cognitive deficits and increased risk of dementia. We utilized postmortem human hippocampal tissue from 26 subjects aged 18–88 years to investigate changes in expression of six genes representing different stages of neurogene...

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Autores principales: Mathews, Kathryn J., Allen, Katherine M., Boerrigter, Danny, Ball, Helen, Shannon Weickert, Cynthia, Double, Kay L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595679/
https://www.ncbi.nlm.nih.gov/pubmed/28766905
http://dx.doi.org/10.1111/acel.12641
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author Mathews, Kathryn J.
Allen, Katherine M.
Boerrigter, Danny
Ball, Helen
Shannon Weickert, Cynthia
Double, Kay L.
author_facet Mathews, Kathryn J.
Allen, Katherine M.
Boerrigter, Danny
Ball, Helen
Shannon Weickert, Cynthia
Double, Kay L.
author_sort Mathews, Kathryn J.
collection PubMed
description Reduced neurogenesis in the aging mammalian hippocampus has been linked to cognitive deficits and increased risk of dementia. We utilized postmortem human hippocampal tissue from 26 subjects aged 18–88 years to investigate changes in expression of six genes representing different stages of neurogenesis across the healthy adult lifespan. Progressive and significant decreases in mRNA levels of the proliferation marker Ki67 (MKI67) and the immature neuronal marker doublecortin (DCX) were found in the healthy human hippocampus over the lifespan. In contrast, expression of genes for the stem cell marker glial fibrillary acidic protein delta and the neuronal progenitor marker eomesodermin was unchanged with age. These data are consistent with a persistence of the hippocampal stem cell population with age. Age‐associated expression of the proliferation and immature neuron markers MKI67 and DCX, respectively, was unrelated, suggesting that neurogenesis‐associated processes are independently altered at these points in the development from stem cell to neuron. These data are the first to demonstrate normal age‐related decreases at specific stages of adult human hippocampal neurogenesis.
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spelling pubmed-55956792017-10-01 Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers Mathews, Kathryn J. Allen, Katherine M. Boerrigter, Danny Ball, Helen Shannon Weickert, Cynthia Double, Kay L. Aging Cell Short Takes Reduced neurogenesis in the aging mammalian hippocampus has been linked to cognitive deficits and increased risk of dementia. We utilized postmortem human hippocampal tissue from 26 subjects aged 18–88 years to investigate changes in expression of six genes representing different stages of neurogenesis across the healthy adult lifespan. Progressive and significant decreases in mRNA levels of the proliferation marker Ki67 (MKI67) and the immature neuronal marker doublecortin (DCX) were found in the healthy human hippocampus over the lifespan. In contrast, expression of genes for the stem cell marker glial fibrillary acidic protein delta and the neuronal progenitor marker eomesodermin was unchanged with age. These data are consistent with a persistence of the hippocampal stem cell population with age. Age‐associated expression of the proliferation and immature neuron markers MKI67 and DCX, respectively, was unrelated, suggesting that neurogenesis‐associated processes are independently altered at these points in the development from stem cell to neuron. These data are the first to demonstrate normal age‐related decreases at specific stages of adult human hippocampal neurogenesis. John Wiley and Sons Inc. 2017-08-01 2017-10 /pmc/articles/PMC5595679/ /pubmed/28766905 http://dx.doi.org/10.1111/acel.12641 Text en © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Takes
Mathews, Kathryn J.
Allen, Katherine M.
Boerrigter, Danny
Ball, Helen
Shannon Weickert, Cynthia
Double, Kay L.
Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers
title Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers
title_full Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers
title_fullStr Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers
title_full_unstemmed Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers
title_short Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers
title_sort evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers
topic Short Takes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595679/
https://www.ncbi.nlm.nih.gov/pubmed/28766905
http://dx.doi.org/10.1111/acel.12641
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