Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1‐mediated autophagy regulation

Aging is accompanied with unfavorable geometric and functional changes in the heart involving dysregulation of Akt and autophagy. This study examined the impact of Akt2 ablation on life span and cardiac aging as well as the mechanisms involved with a focus on autophagy and mitochondrial integrity. C...

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Detalles Bibliográficos
Autores principales: Ren, Jun, Yang, Lifang, Zhu, Li, Xu, Xihui, Ceylan, Asli F., Guo, Wei, Yang, Jian, Zhang, Yingmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595687/
https://www.ncbi.nlm.nih.gov/pubmed/28681509
http://dx.doi.org/10.1111/acel.12616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595687/
https://www.ncbi.nlm.nih.gov/pubmed/28681509
http://dx.doi.org/10.1111/acel.12616

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