Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration

Alpha synuclein (α-syn) is a central player in neurodegeneration, but the mechanisms triggering its pathology are not fully understood. Here we found that α-syn is a highly efficient substrate for arginyltransferase ATE1 and is arginylated in vivo by a novel mid-chain mechanism that targets the acid...

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Detalles Bibliográficos
Autores principales: Wang, Junling, Han, Xuemei, Leu, Nicolae Adrian, Sterling, Stephanie, Kurosaka, Satoshi, Fina, Marie, Lee, Virginia M., Dong, Dawei W., Yates, John R., Kashina, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595787/
https://www.ncbi.nlm.nih.gov/pubmed/28900170
http://dx.doi.org/10.1038/s41598-017-11713-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595787/
https://www.ncbi.nlm.nih.gov/pubmed/28900170
http://dx.doi.org/10.1038/s41598-017-11713-z

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