GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis

The mitochondrial enriched GCN5-like 1 (GCN5L1) protein has been shown to modulate mitochondrial protein acetylation, mitochondrial content and mitochondrial retrograde signaling. Here we show that hepatic GCN5L1 ablation reduces fasting glucose levels and blunts hepatic gluconeogenesis without affe...

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Detalles Bibliográficos
Autores principales: Wang, Lingdi, Scott, Iain, Zhu, Lu, Wu, Kaiyuan, Han, Kim, Chen, Yong, Gucek, Marjan, Sack, Michael N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595826/
https://www.ncbi.nlm.nih.gov/pubmed/28900165
http://dx.doi.org/10.1038/s41467-017-00521-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595826/
https://www.ncbi.nlm.nih.gov/pubmed/28900165
http://dx.doi.org/10.1038/s41467-017-00521-8

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