Cargando…
Dynamic and Kinetic Elements of µ-Opioid Receptor Functional Selectivity
While the therapeutic effect of opioids analgesics is mainly attributed to µ-opioid receptor (MOR) activation leading to G protein signaling, their side effects have mostly been linked to β-arrestin signaling. To shed light on the dynamic and kinetic elements underlying MOR functional selectivity, w...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595830/ https://www.ncbi.nlm.nih.gov/pubmed/28900175 http://dx.doi.org/10.1038/s41598-017-11483-8 |