Nectin-like molecule-4/cell adhesion molecule 4 inhibits the ligand-induced dimerization of ErbB3 with ErbB2

The ligand-induced dimerization of cell surface single-transmembrane receptors is essential for their activation. However, physiological molecules that inhibit their dimerization and activation have not been identified. ErbB3 dimerizes with ErbB2 upon binding of heregulin (HRG) to ErbB3, causing the...

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Detalles Bibliográficos
Autores principales: Mizutani, Kiyohito, Kedashiro, Shin, Maruoka, Masahiro, Ueda, Yuki, Takai, Yoshimi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595929/
https://www.ncbi.nlm.nih.gov/pubmed/28900130
http://dx.doi.org/10.1038/s41598-017-10107-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595929/
https://www.ncbi.nlm.nih.gov/pubmed/28900130
http://dx.doi.org/10.1038/s41598-017-10107-5

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