Synthesis and Evaluation of GM2-Monophosphoryl Lipid A Conjugate as a Fully Synthetic Self-Adjuvant Cancer Vaccine

An efficient method was developed for the synthesis of a GM2 derivative suitable for the conjugation with various biomolecules. This GM2 derivative was covalently linked to keyhole limpet hemocyanin (KLH) and monophosphoryl lipid A (MPLA) to form novel therapeutic cancer vaccines. Immunological eval...

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Detalles Bibliográficos
Autores principales: Zhou, Zhifang, Mandal, Satadru S., Liao, Guochao, Guo, Jiatong, Guo, Zhongwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595996/
https://www.ncbi.nlm.nih.gov/pubmed/28900154
http://dx.doi.org/10.1038/s41598-017-11500-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595996/
https://www.ncbi.nlm.nih.gov/pubmed/28900154
http://dx.doi.org/10.1038/s41598-017-11500-w

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