Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD90

Cancer stem cells (CSCs) are a pivotal target for eradicating hepatocellular carcinoma (HCC). We previously reported that distinctive CSCs regulating tumorigenicity (EpCAM(+) CSCs) and metastasis (CD90(+) CSCs) have different epithelial/mesenchymal gene expression signatures. Here, we examined the i...

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Detalles Bibliográficos
Autores principales: Yoshida, Mariko, Yamashita, Taro, Okada, Hikari, Oishi, Naoki, Nio, Kouki, Hayashi, Takehiro, Nomura, Yoshimoto, Hayashi, Tomoyuki, Asahina, Yoshiro, Ohwada, Mika, Sunagozaka, Hajime, Takatori, Hajime, Colombo, Federico, Porretti, Laura, Honda, Masao, Kaneko, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596021/
https://www.ncbi.nlm.nih.gov/pubmed/28900199
http://dx.doi.org/10.1038/s41598-017-11848-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596021/
https://www.ncbi.nlm.nih.gov/pubmed/28900199
http://dx.doi.org/10.1038/s41598-017-11848-z

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