Critical role of Myc activation in mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways

MYC activation at modest levels has been frequently found in hepatocellular carcinoma. However, its significance in hepatocarcinogenesis has remained obscure. Here we examined the role of Myc activation in mouse liver tumours induced by hepatocytic expression of myristoylated AKT (AKT) and/or mutant...

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Detalles Bibliográficos
Autores principales: Xin, B, Yamamoto, M, Fujii, K, Ooshio, T, Chen, X, Okada, Y, Watanabe, K, Miyokawa, N, Furukawa, H, Nishikawa, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596209/
https://www.ncbi.nlm.nih.gov/pubmed/28481866
http://dx.doi.org/10.1038/onc.2017.114

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