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Sirtuin Lipoamidase Activity Is Conserved in Bacteria as a Regulator of Metabolic Enzyme Complexes

Lipoic acid is an essential metabolic cofactor added as a posttranslational modification on several multimeric enzyme complexes. These protein complexes, evolutionarily conserved from bacteria to humans, are core regulators of cellular metabolism. While the multistep enzymatic process of adding lipo...

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Detalles Bibliográficos
Autores principales: Rowland, Elizabeth A., Greco, Todd M., Snowden, Caroline K., McCabe, Anne L., Silhavy, Thomas J., Cristea, Ileana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596343/
https://www.ncbi.nlm.nih.gov/pubmed/28900027
http://dx.doi.org/10.1128/mBio.01096-17