Alternatively spliced MEFV transcript lacking exon 2 and its protein isoform pyrin-2d implies an epigenetic regulation of the gene in inflammatory cell culture models

The function of gene body DNA methylation in alternative splicing, and its relation to disease pathogenesis is not fully elucidated. The gene for familial Mediterranean fever (MEFV) encodes the pyrin protein and contains a 998 bp CpG island, covering the second exon, which is differentially methylat...

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Detalles Bibliográficos
Autores principales: Erdem, Gokce Celikyapi, Erdemir, Sule, Abaci, Irem, Aydin, Asli K. Kirectepe, Everest, Elif, Turanli, Eda Tahir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2017
Materias:
Cellular, Molecular and Developmental Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596369/
https://www.ncbi.nlm.nih.gov/pubmed/28863210
http://dx.doi.org/10.1590/1678-4685-GMB-2016-0234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596369/
https://www.ncbi.nlm.nih.gov/pubmed/28863210
http://dx.doi.org/10.1590/1678-4685-GMB-2016-0234

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