Cargando…

In vivo chemotherapeutic insight of a novel isocoumarin (3-hexyl-5,7-dimethoxy-isochromen-1-one): Genotoxicity, cell death induction, leukometry and phagocytic evaluation

Chemotherapy is one of the major approaches for the treatment of cancer. Therefore, the development of new chemotherapy drugs is an important aspect of medicinal chemistry. Chemotherapeutic agents include isocoumarins, which are privileged structures with potential antitumoral activity. Herein, a ne...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Araújo, Flávio Henrique Souza, de Figueiredo, Débora Rojas, Auharek, Sarah Alves, Pesarini, João Renato, Meza, Alisson, Gomes, Roberto da Silva, Monreal, Antônio Carlos Duenhas, Antoniolli-Silva, Andréia Conceição Milan Brochado, de Lima, Dênis Pires, Kassuya, Candida Aparecida Leite, Beatriz, Adilson, Oliveira, Rodrigo Juliano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Sociedade Brasileira de Genética 2017
Materias:	Mutagenesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596378/ https://www.ncbi.nlm.nih.gov/pubmed/28898353 http://dx.doi.org/10.1590/1678-4685-GMB-2016-0316

Ejemplares similares

Assessment of the toxicogenic effects and cell death potential of the ester (Z)-methyl 4-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-4-oxobut-2-anoate in combination with cisplatin, cyclophosphamide and doxorubicin
por: Juliano Oliveira, Rodrigo, et al.
Publicado: (2019)

Assessment of genetic integrity, splenic phagocytosis and cell death potential of (Z)-4-((1,5-dimethyl-3-oxo-2-phenyl-2,3dihydro-1H-pyrazol-4-yl) amino)-4-oxobut-2-enoic acid and its effect when combined with commercial chemotherapeutics
por: Oliveira, Rodrigo Juliano, et al.
Publicado: (2018)

Cardanol: toxicogenetic assessment and its effects when combined with cyclophosphamide
por: Schneider, Beatriz Ursinos Catelan, et al.
Publicado: (2016)

In vivo evaluation of the antimutagenic and antigenotoxic effects of β-glucan extracted from Saccharomyces cerevisiae in acute treatment with multiple doses
por: Oliveira, Rodrigo Juliano, et al.
Publicado: (2013)

Effects of β-glucan polysaccharide revealed by the dominant lethal assay and micronucleus assays, and reproductive performance of male mice exposed to cyclophosphamide
por: Oliveira, Rodrigo Juliano, et al.
Publicado: (2014)

Ecophysiology, genotoxicity, histopathology, and gene responses of naphthalene injected Colossoma macropomum (Cuvier, 1818) exposed to hypoxia
por: de Souza, Samara Silva, et al.
Publicado: (2019)

Protective effects of acerola juice on genotoxicity induced by iron in vivo
por: Horta, Roberta Nunes, et al.
Publicado: (2016)

Ras oncogene and Hypoxia-inducible factor-1 alpha (hif-1α) expression in the Amazon fish Colossoma macropomum (Cuvier, 1818) exposed to benzo[a]pyrene.
por: da Silva, Grazyelle Sebrenski, et al.
Publicado: (2017)

Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure
por: Torres-Ávila, Jose F., et al.
Publicado: (2020)

Evaluation of the mutagenicity and antimutagenicity of Ziziphus joazeiro Mart. bark in the micronucleus assay
por: Boriollo, Marcelo Fabiano Gomes, et al.
Publicado: (2014)

DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster
por: da Silva, Robson Alves, et al.
Publicado: (2016)

Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster
por: Jacociunas, Laura Vicedo, et al.
Publicado: (2014)

Modulatory effects of Tabebuia impetiginosa (Lamiales, Bignoniaceae) on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster
por: de Sousa, Neila C., et al.
Publicado: (2009)

Cis-trimethoxystilbene, exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in MCF-7 and MCF-10A cell lines
por: Gonçalves, Natália dos Santos, et al.
Publicado: (2021)

LNO3 AND L3 Are Associated With Antiproliferative And Pro-Apoptotic Action In Hepatoma Cells
por: Zanelatto, Leonardo Campos, et al.
Publicado: (2016)

Studies of micronuclei and other nuclear abnormalities in red blood cells of Colossoma macropomum exposed to methylmercury
por: da Rocha, Carlos Alberto Machado, et al.
Publicado: (2011)

Protective effects of bark ethanolic extract from Spondias dulcis Forst F. against DNA damage induced by benzo[a]pyrene and cyclophosphamide
por: Araujo, Caroline de S., et al.
Publicado: (2019)

Toxicity and genotoxicity in Astyanax bimaculatus (Characidae) induced by microcystins from a bloom of Microcystis spp
por: da Silva, Ricardo Rocha Pavan, et al.
Publicado: (2010)

Genotoxic effects of Tabebuia impetiginosa (Mart. Ex DC.) Standl. (Lamiales, Bignoniaceae) extract in Wistar rats
por: Lemos, Odilon A., et al.
Publicado: (2012)

Genotoxicity of Nicotiana tabacum leaves on Helix aspersa
por: da Silva, Fernanda R., et al.
Publicado: (2013)

Sewage sludge does not induce genotoxicity and carcinogenesis
por: Silva, Paula Regina Pereira, et al.
Publicado: (2012)

Cytotoxic and genotoxic evaluation of cotinine using human neuroblastoma cells (SH-SY5Y)
por: Dalberto, Daiana, et al.
Publicado: (2020)

Influence of environmental dust in transformation capacity of Streptococcus pneumoniae
por: de Oliveira, José Diogo, et al.
Publicado: (2020)

Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)
por: de Almeida, Pedro Marcos, et al.
Publicado: (2015)

Evaluation of genetic damage induced by glyphosate isopropylamine salt using Tradescantia bioassays
por: Alvarez-Moya, Carlos, et al.
Publicado: (2011)

Genotoxicity assessment of Copaiba oil and its fractions in Swiss mice
por: Almeida, Mara Ribeiro, et al.
Publicado: (2012)

Determination of the antimutagenicity of an aqueous extract of Rhizophora mangle L. (Rhizophoraceae), using in vivo and in vitro test systems
por: Malini, Maressa, et al.
Publicado: (2010)

Comparison of the in vivo and in vitro genotoxicity of glyphosate isopropylamine salt in three different organisms
por: Alvarez-Moya, Carlos, et al.
Publicado: (2014)

Basal levels of inorganic elements, genetic damages, and hematological values in captive Falco peregrinus
por: Stocker, Julian, et al.
Publicado: (2022)

Genotoxicity of lapachol evaluated by wing spot test of Drosophila melanogaster
por: Costa, Wender Ferreira, et al.
Publicado: (2010)

Profile of micronucleus frequencies and DNA damage in different species of fish in a eutrophic tropical lake
por: Grisolia, Cesar K., et al.
Publicado: (2009)

Cytotoxicity and genotoxicity of stilbene derivatives in CHO-K1 and HepG2 cell lines
por: Mizuno, Cassia Suemi, et al.
Publicado: (2017)

Chromosomal damage and apoptosis analysis in exfoliated oral epithelial cells from mouthwash and alcohol users
por: Rocha, Rodrigo dos Santos, et al.
Publicado: (2014)

Alterations in gene expression profiles correlated with cisplatin cytotoxicity in the glioma U343 cell line
por: Carminati, Patricia Oliveira, et al.
Publicado: (2010)

Effect of organic tomato (Lycopersicon esculentum) extract on the genotoxicity of doxorubicin in the Drosophila wing spot test
por: Dutra, Elaine S., et al.
Publicado: (2009)

The lipidome, genotoxicity, hematotoxicity and antioxidant properties of andiroba oil from the Brazilian Amazon
por: Milhomem-Paixão, Susana Suely Rodrigues, et al.
Publicado: (2016)

Profile of micronucleus frequencies and nuclear abnormalities in different species of electric fishes (Gymnotiformes) from the Eastern Amazon
por: Melo, Karina Motta, et al.
Publicado: (2013)

Multi-level toxicity assessment of the antidepressant venlafaxine in embryos/larvae and adults of zebrafish (Danio rerio)
por: Oliveira, Ana Clara, et al.
Publicado: (2023)

Cytogenotoxicity biomarkers in fat snook Centropomus parallelus from Cananéia and São Vicente estuaries, SP, Brazil
por: Kirschbaum, Aline A., et al.
Publicado: (2009)

Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer
por: Magnani, Marciane, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_83q55tsneh69n533a6pl6g6c87