TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

Recent studies have suggested increased plasticity of differentiated cells within the intestine to act both as intestinal stem cells (ISCs) and tumour-initiating cells. However, little is known of the processes that regulate this plasticity. Our previous work has shown that activating mutations of K...

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Detalles Bibliográficos
Autores principales: Cammareri, Patrizia, Vincent, David F, Hodder, Michael C, Ridgway, Rachel A, Murgia, Claudio, Nobis, Max, Campbell, Andrew D, Varga, Julia, Huels, David J, Subramani, Chithra, Prescott, Katie L H, Nixon, Colin, Hedley, Ann, Barry, Simon T, Greten, Florian R, Inman, Gareth J, Sansom, Owen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596428/
https://www.ncbi.nlm.nih.gov/pubmed/28622298
http://dx.doi.org/10.1038/cdd.2017.92

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596428/
https://www.ncbi.nlm.nih.gov/pubmed/28622298
http://dx.doi.org/10.1038/cdd.2017.92

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