Brusatol-Mediated Inhibition of c-Myc Increases HIF-1α Degradation and Causes Cell Death in Colorectal Cancer under Hypoxia

HIF-1 (hypoxia-inducible factor-1) regulates the expression of ~100 genes involved in angiogenesis, metastasis, tumor growth, chemoresistance and radioresistance, underscoring the growing interest in targeting HIF-1 for cancer control. In the present study, we investigated the molecular mechanisms u...

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Detalles Bibliográficos
Autores principales: Oh, Eun-Taex, Kim, Chan Woo, Kim, Ha Gyeong, Lee, Jae-Seon, Park, Heon Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596433/
https://www.ncbi.nlm.nih.gov/pubmed/28912885
http://dx.doi.org/10.7150/thno.20861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596433/
https://www.ncbi.nlm.nih.gov/pubmed/28912885
http://dx.doi.org/10.7150/thno.20861

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