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Brusatol-Mediated Inhibition of c-Myc Increases HIF-1α Degradation and Causes Cell Death in Colorectal Cancer under Hypoxia
HIF-1 (hypoxia-inducible factor-1) regulates the expression of ~100 genes involved in angiogenesis, metastasis, tumor growth, chemoresistance and radioresistance, underscoring the growing interest in targeting HIF-1 for cancer control. In the present study, we investigated the molecular mechanisms u...
Autores principales: | Oh, Eun-Taex, Kim, Chan Woo, Kim, Ha Gyeong, Lee, Jae-Seon, Park, Heon Joo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596433/ https://www.ncbi.nlm.nih.gov/pubmed/28912885 http://dx.doi.org/10.7150/thno.20861 |
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