Hyperosmotic stress enhances cytotoxicity of SMAC mimetics

Inhibitors of apoptosis (IAP) proteins contribute to cell death resistance in malignancies and emerged as promising targets in cancer therapy. Currently, small molecules mimicking the IAP-antagonizing activity of endogenous second mitochondria-derived activator of caspases (SMAC) are evaluated in ph...

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Detalles Bibliográficos
Autores principales: Bittner, Sebastian, Knoll, Gertrud, Ehrenschwender, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596546/
https://www.ncbi.nlm.nih.gov/pubmed/28771230
http://dx.doi.org/10.1038/cddis.2017.355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596546/
https://www.ncbi.nlm.nih.gov/pubmed/28771230
http://dx.doi.org/10.1038/cddis.2017.355

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