HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis

BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells overexpressing heat shock protein B1 (HSPB1 or HSP27) and that this is due to enhance...

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Detalles Bibliográficos
Autores principales: Kennedy, Donna, Mnich, Katarzyna, Oommen, Deepu, Chakravarthy, Reka, Almeida-Souza, Leonardo, Krols, Michiel, Saveljeva, Svetlana, Doyle, Karen, Gupta, Sanjeev, Timmerman, Vincent, Janssens, Sophie, Gorman, Adrienne M, Samali, Afshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596589/
https://www.ncbi.nlm.nih.gov/pubmed/29048431
http://dx.doi.org/10.1038/cddis.2017.408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596589/
https://www.ncbi.nlm.nih.gov/pubmed/29048431
http://dx.doi.org/10.1038/cddis.2017.408

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