Cargando…

HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis

BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells overexpressing heat shock protein B1 (HSPB1 or HSP27) and that this is due to enhance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kennedy, Donna, Mnich, Katarzyna, Oommen, Deepu, Chakravarthy, Reka, Almeida-Souza, Leonardo, Krols, Michiel, Saveljeva, Svetlana, Doyle, Karen, Gupta, Sanjeev, Timmerman, Vincent, Janssens, Sophie, Gorman, Adrienne M, Samali, Afshin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596589/ https://www.ncbi.nlm.nih.gov/pubmed/29048431 http://dx.doi.org/10.1038/cddis.2017.408

Ejemplares similares

Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders
por: Doyle, Karen M, et al.
Publicado: (2011)

Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival
por: Saveljeva, Svetlana, et al.
Publicado: (2016)

Endoplasmic Reticulum Stress-Regulated Chaperones as a Serum Biomarker Panel for Parkinson’s Disease
por: Mnich, Katarzyna, et al.
Publicado: (2022)

Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response
por: Samali, Afshin, et al.
Publicado: (2010)

Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells
por: Saveljeva, S, et al.
Publicado: (2015)

Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM
por: Kennedy, Donna, et al.
Publicado: (2014)

HSPB1 Facilitates the Formation of Non-Centrosomal Microtubules
por: Almeida-Souza, Leonardo, et al.
Publicado: (2013)

Proteostasis Regulation in the Endoplasmic Reticulum: An Emerging Theme in the Molecular Pathology and Therapeutic Management of Familial Hypercholesterolemia
por: Oommen, Deepu, et al.
Publicado: (2020)

Endoplasmic reticulum stress signalling – from basic mechanisms to clinical applications
por: Almanza, Aitor, et al.
Publicado: (2018)

Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion viaregulation of Bim
por: Szegezdi, E, et al.
Publicado: (2008)

Regulation of lipid metabolism by the unfolded protein response
por: Moncan, Matthieu, et al.
Publicado: (2021)

Mitochondria-associated membranes as hubs for neurodegeneration
por: Krols, Michiel, et al.
Publicado: (2016)

ER–Mitochondria contact sites: A new regulator of cellular calcium flux comes into play
por: Krols, Michiel, et al.
Publicado: (2016)

An Emerging Role for the Unfolded Protein Response in Pancreatic Cancer
por: Robinson, Claire M., et al.
Publicado: (2021)

New insights into IRE1α activation and function in anti-tumor immunity
por: Logue, Susan E., et al.
Publicado: (2022)

Cellular Stress Responses: Cell Survival and Cell Death
por: Fulda, Simone, et al.
Publicado: (2010)

Mutant HSPB8 causes motor neuron-specific neurite degeneration
por: Irobi, Joy, et al.
Publicado: (2010)

Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions
por: Deegan, Shane, et al.
Publicado: (2014)

HSPB1, HSPB6, HSPB7 and HSPB8 Protect against RhoA GTPase-Induced Remodeling in Tachypaced Atrial Myocytes
por: Ke, Lei, et al.
Publicado: (2011)

Human HspB1, HspB3, HspB5 and HspB8: Shaping these disease factors during vertebrate evolution
por: Benndorf, Rainer, et al.
Publicado: (2022)

Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion
por: Cawley, Karen, et al.
Publicado: (2013)

The Unfolded Protein Response in Breast Cancer
por: McGrath, Eoghan P., et al.
Publicado: (2018)

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity
por: Wali, J A, et al.
Publicado: (2014)

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance
por: Miani, M, et al.
Publicado: (2013)

Increased Monomerization of Mutant HSPB1 Leads to Protein Hyperactivity in Charcot-Marie-Tooth Neuropathy
por: Almeida-Souza, Leonardo, et al.
Publicado: (2010)

THE ENDOPLASMIC RETICULUM
por: Palade, George E.
Publicado: (1956)

The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8
por: Shatov, Vladislav M., et al.
Publicado: (2018)

Cell Stress and Cell Death
por: Samali, Afshin, et al.
Publicado: (2010)

Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors
por: Carlesso, Antonio, et al.
Publicado: (2019)

Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain
por: Carlesso, Antonio, et al.
Publicado: (2018)

Effect of Kinase Inhibiting RNase Attenuator (KIRA) Compounds on the Formation of Face-to-Face Dimers of Inositol-Requiring Enzyme 1: Insights from Computational Modeling
por: Carlesso, Antonio, et al.
Publicado: (2019)

Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1
por: Chintha, Chetan, et al.
Publicado: (2020)

The stressosome, a caspase‐8‐activating signalling complex assembled in response to cell stress in an ATG5‐mediated manner
por: Mnich, Katarzyna, et al.
Publicado: (2021)

HspB1, HspB5 and HspB4 in Human Cancers: Potent Oncogenic Role of Some of Their Client Proteins
por: Arrigo, André-Patrick, et al.
Publicado: (2014)

Insights into the structure and function of the RNA ligase RtcB
por: Moncan, Matthieu, et al.
Publicado: (2023)

Construction of the endoplasmic reticulum
Publicado: (1989)

Sensory neuropathy-causing mutations in ATL3 affect ER–mitochondria contact sites and impair axonal mitochondrial distribution
por: Krols, Michiel, et al.
Publicado: (2019)

A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8
por: Bouhy, Delphine, et al.
Publicado: (2017)

Preconditioning with Endoplasmic Reticulum Stress Ameliorates Endothelial Cell Inflammation
por: Leonard, Antony, et al.
Publicado: (2014)

Characterization of Hspb8 in Zebrafish
por: Dubińska-Magiera, Magda, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v64iseht2ibsaan7qpradrtmmq