Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the “insulin paradox”). Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber sy...

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Detalles Bibliográficos
Autores principales: Augustin, Hrvoje, McGourty, Kieran, Allen, Marcus J., Madem, Sirisha Kudumala, Adcott, Jennifer, Kerr, Fiona, Wong, Chi Tung, Vincent, Alec, Godenschwege, Tanja, Boucrot, Emmanuel, Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597081/
https://www.ncbi.nlm.nih.gov/pubmed/28902870
http://dx.doi.org/10.1371/journal.pbio.2001655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597081/
https://www.ncbi.nlm.nih.gov/pubmed/28902870
http://dx.doi.org/10.1371/journal.pbio.2001655

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