Dendrimer-based selective autophagy-induction rescues ΔF508-CFTR and inhibits Pseudomonas aeruginosa infection in cystic fibrosis

BACKGROUND: Cystic Fibrosis (CF) is a genetic disorder caused by mutation(s) in the CF-transmembrane conductance regulator (Cftr) gene. The most common mutation, ΔF508, leads to accumulation of defective-CFTR protein in aggresome-bodies. Additionally, Pseudomonas aeruginosa (Pa), a common CF pathoge...

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Detalles Bibliográficos
Autores principales: Brockman, Scott Mackenzie, Bodas, Manish, Silverberg, David, Sharma, Ajit, Vij, Neeraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597233/
https://www.ncbi.nlm.nih.gov/pubmed/28902888
http://dx.doi.org/10.1371/journal.pone.0184793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597233/
https://www.ncbi.nlm.nih.gov/pubmed/28902888
http://dx.doi.org/10.1371/journal.pone.0184793

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