Frontline Science: Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma

The pathophysiology of allergic asthma is driven by Th2 immune responses after aeroallergen inhalation. The mechanisms that initiate, potentiate, and regulate airway allergy are incompletely characterized. We have shown that Hh signaling to T cells, via downstream Gli transcription factors, enhances...

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Detalles Bibliográficos
Autores principales: Standing, Ariane S. I., Yánez, Diana C., Ross, Rosie, Crompton, Tessa, Furmanski, Anna L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Leukocyte Biology 2017
Materias:
Spotlight on Leading Edge Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597515/
https://www.ncbi.nlm.nih.gov/pubmed/28235772
http://dx.doi.org/10.1189/jlb.3HI1016-438RR

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597515/
https://www.ncbi.nlm.nih.gov/pubmed/28235772
http://dx.doi.org/10.1189/jlb.3HI1016-438RR

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