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BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
Mutations in the tumor suppressor BRCA2 predominantly predispose to breast cancer. Paradoxically, while loss of BRCA2 promotes tumor formation, it also causes cell lethality, although how lethality is triggered is unclear. Here, we generate BRCA2 conditional non-transformed human mammary epithelial...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597640/ https://www.ncbi.nlm.nih.gov/pubmed/28904335 http://dx.doi.org/10.1038/s41467-017-00634-0 |