Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?

This paper investigates cell proliferation dynamics in small tumor cell aggregates using an individual-based model (IBM). The simulation model is designed to study the morphology of the cell population and of the cell lineages as well as the impact of the orientation of the division plane on this mo...

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Detalles Bibliográficos
Autores principales: Leroy-Lerêtre, Mathieu, Dimarco, Giacomo, Cazales, Martine, Boizeau, Marie-Laure, Ducommun, Bernard, Lobjois, Valérie, Degond, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597711/
https://www.ncbi.nlm.nih.gov/pubmed/28852950
http://dx.doi.org/10.1007/s11538-017-0333-y
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author Leroy-Lerêtre, Mathieu
Dimarco, Giacomo
Cazales, Martine
Boizeau, Marie-Laure
Ducommun, Bernard
Lobjois, Valérie
Degond, Pierre
author_facet Leroy-Lerêtre, Mathieu
Dimarco, Giacomo
Cazales, Martine
Boizeau, Marie-Laure
Ducommun, Bernard
Lobjois, Valérie
Degond, Pierre
author_sort Leroy-Lerêtre, Mathieu
collection PubMed
description This paper investigates cell proliferation dynamics in small tumor cell aggregates using an individual-based model (IBM). The simulation model is designed to study the morphology of the cell population and of the cell lineages as well as the impact of the orientation of the division plane on this morphology. Our IBM model is based on the hypothesis that cells are incompressible objects that grow in size and divide once a threshold size is reached, and that newly born cell adhere to the existing cell cluster. We performed comparisons between the simulation model and experimental data by using several statistical indicators. The results suggest that the emergence of particular morphologies can be explained by simple mechanical interactions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11538-017-0333-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-55977112017-10-02 Are Tumor Cell Lineages Solely Shaped by Mechanical Forces? Leroy-Lerêtre, Mathieu Dimarco, Giacomo Cazales, Martine Boizeau, Marie-Laure Ducommun, Bernard Lobjois, Valérie Degond, Pierre Bull Math Biol Original Article This paper investigates cell proliferation dynamics in small tumor cell aggregates using an individual-based model (IBM). The simulation model is designed to study the morphology of the cell population and of the cell lineages as well as the impact of the orientation of the division plane on this morphology. Our IBM model is based on the hypothesis that cells are incompressible objects that grow in size and divide once a threshold size is reached, and that newly born cell adhere to the existing cell cluster. We performed comparisons between the simulation model and experimental data by using several statistical indicators. The results suggest that the emergence of particular morphologies can be explained by simple mechanical interactions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11538-017-0333-y) contains supplementary material, which is available to authorized users. Springer US 2017-08-29 2017 /pmc/articles/PMC5597711/ /pubmed/28852950 http://dx.doi.org/10.1007/s11538-017-0333-y Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Leroy-Lerêtre, Mathieu
Dimarco, Giacomo
Cazales, Martine
Boizeau, Marie-Laure
Ducommun, Bernard
Lobjois, Valérie
Degond, Pierre
Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?
title Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?
title_full Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?
title_fullStr Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?
title_full_unstemmed Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?
title_short Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?
title_sort are tumor cell lineages solely shaped by mechanical forces?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597711/
https://www.ncbi.nlm.nih.gov/pubmed/28852950
http://dx.doi.org/10.1007/s11538-017-0333-y
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