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Existence of Brain 5-HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5-HT1A Receptor Recognition

[Image: see text] Studies on serotonin-selective reuptake inhibitors have established that disturbances in the ascending 5-HT neuron systems and their 5-HT receptor subtypes and collateral networks to the forebrain contribute to the etiology of major depression and are targets for treatment. The the...

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Detalles Bibliográficos
Autores principales: Borroto-Escuela, Dasiel O., Li, Xiang, Tarakanov, Alexander O., Savelli, David, Narváez, Manuel, Shumilov, Kirill, Andrade-Talavera, Yuniesky, Jimenez-Beristain, Antonio, Pomierny, Bartosz, Díaz-Cabiale, Zaida, Cuppini, Riccardo, Ambrogini, Patrizia, Lindskog, Maria, Fuxe, Kjell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597955/
https://www.ncbi.nlm.nih.gov/pubmed/28920103
http://dx.doi.org/10.1021/acsomega.7b00629