Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

Parkinson’s disease (PD) pathophysiology develops in part from the formation, transmission, and aggregation of toxic species of the protein α-synuclein (α-syn). Recent evidence suggests that extracellular vesicles (EVs) may play a vital role in the transport of toxic α-syn between brain regions. Mor...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsumoto, Junichi, Stewart, Tessandra, Sheng, Lifu, Li, Na, Bullock, Kristin, Song, Ning, Shi, Min, Banks, William A, Zhang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598000/
https://www.ncbi.nlm.nih.gov/pubmed/28903781
http://dx.doi.org/10.1186/s40478-017-0470-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598000/
https://www.ncbi.nlm.nih.gov/pubmed/28903781
http://dx.doi.org/10.1186/s40478-017-0470-4

Ejemplares similares