Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis

BACKGROUND: B-cell chronic lymphocytic leukemia (CLL) is a common type of adult leukemia. It often follows an indolent course and is preceded by monoclonal B-cell lymphocytosis, an asymptomatic condition, however it is not known what causes subjects with this condition to progress to CLL. Hence the...

Descripción completa

Detalles Bibliográficos
Autores principales: Georgiadis, Panagiotis, Liampa, Irene, Hebels, Dennie G., Krauskopf, Julian, Chatziioannou, Aristotelis, Valavanis, Ioannis, de Kok, Theo M.C.M., Kleinjans, Jos C.S., Bergdahl, Ingvar A., Melin, Beatrice, Spaeth, Florentin, Palli, Domenico, Vermeulen, R.C.H., Vlaanderen, J., Chadeau-Hyam, Marc, Vineis, Paolo, Kyrtopoulos, Soterios A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598006/
https://www.ncbi.nlm.nih.gov/pubmed/28903739
http://dx.doi.org/10.1186/s12864-017-4117-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598006/
https://www.ncbi.nlm.nih.gov/pubmed/28903739
http://dx.doi.org/10.1186/s12864-017-4117-4

Ejemplares similares