Co-administration of fresh grape fruit juice (GFJ) and bergamottin prevented paracetamol induced hepatotoxicity after paracetamol overdose in rats

The aim of this study was to evaluate small doses of known cytochrome P450 enzyme inhibitors, grapefruit juice (GFJ) and one of its components, bergamottin (BGT), for the prevention of paracetamol (PAR)-induced hepatotoxicity after overdose in rats. Six groups of 15 Sprague Dawley (SD) rats each wer...

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Detalles Bibliográficos
Autores principales: Baleni, Refuoe, Bekker, Zanelle, Walubo, Andrew, Du Plessis, Jan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598241/
https://www.ncbi.nlm.nih.gov/pubmed/28962403
http://dx.doi.org/10.1016/j.toxrep.2015.05.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598241/
https://www.ncbi.nlm.nih.gov/pubmed/28962403
http://dx.doi.org/10.1016/j.toxrep.2015.05.004

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