1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect

Addition of DMPC considerably inhibits the degradation of Carmofur in neutral phosphate buffer solutions and this drug becomes less influenced by pH. Carmofur stabilization at neutral pH caused by DMPC addition for in vitro studies was characterized and monitored by (1)H NMR. Antiproliferative activ...

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Detalles Bibliográficos
Autores principales: Domracheva, Ilona, Muhamadejev, Ruslan, Petrova, Marina, Liepinsh, Edvards, Gulbe, Anita, Shestakova, Irina, Duburs, Gunars, Arsenyan, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598257/
https://www.ncbi.nlm.nih.gov/pubmed/28962371
http://dx.doi.org/10.1016/j.toxrep.2015.01.009
Descripción
Sumario:Addition of DMPC considerably inhibits the degradation of Carmofur in neutral phosphate buffer solutions and this drug becomes less influenced by pH. Carmofur stabilization at neutral pH caused by DMPC addition for in vitro studies was characterized and monitored by (1)H NMR. Antiproliferative activity studies on various tumor cell lines showed considerable increase of Carmofur ability to prevent tumor cell growth, when it is added as a mixture with DMPC. This technique opens a way for Carmofur drug delivery in neutral and basic media.

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