1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect

Addition of DMPC considerably inhibits the degradation of Carmofur in neutral phosphate buffer solutions and this drug becomes less influenced by pH. Carmofur stabilization at neutral pH caused by DMPC addition for in vitro studies was characterized and monitored by (1)H NMR. Antiproliferative activ...

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Autores principales: Domracheva, Ilona, Muhamadejev, Ruslan, Petrova, Marina, Liepinsh, Edvards, Gulbe, Anita, Shestakova, Irina, Duburs, Gunars, Arsenyan, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598257/
https://www.ncbi.nlm.nih.gov/pubmed/28962371
http://dx.doi.org/10.1016/j.toxrep.2015.01.009
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author Domracheva, Ilona
Muhamadejev, Ruslan
Petrova, Marina
Liepinsh, Edvards
Gulbe, Anita
Shestakova, Irina
Duburs, Gunars
Arsenyan, Pavel
author_facet Domracheva, Ilona
Muhamadejev, Ruslan
Petrova, Marina
Liepinsh, Edvards
Gulbe, Anita
Shestakova, Irina
Duburs, Gunars
Arsenyan, Pavel
author_sort Domracheva, Ilona
collection PubMed
description Addition of DMPC considerably inhibits the degradation of Carmofur in neutral phosphate buffer solutions and this drug becomes less influenced by pH. Carmofur stabilization at neutral pH caused by DMPC addition for in vitro studies was characterized and monitored by (1)H NMR. Antiproliferative activity studies on various tumor cell lines showed considerable increase of Carmofur ability to prevent tumor cell growth, when it is added as a mixture with DMPC. This technique opens a way for Carmofur drug delivery in neutral and basic media.
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spelling pubmed-55982572017-09-28 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect Domracheva, Ilona Muhamadejev, Ruslan Petrova, Marina Liepinsh, Edvards Gulbe, Anita Shestakova, Irina Duburs, Gunars Arsenyan, Pavel Toxicol Rep Short Communication Addition of DMPC considerably inhibits the degradation of Carmofur in neutral phosphate buffer solutions and this drug becomes less influenced by pH. Carmofur stabilization at neutral pH caused by DMPC addition for in vitro studies was characterized and monitored by (1)H NMR. Antiproliferative activity studies on various tumor cell lines showed considerable increase of Carmofur ability to prevent tumor cell growth, when it is added as a mixture with DMPC. This technique opens a way for Carmofur drug delivery in neutral and basic media. Elsevier 2015-01-27 /pmc/articles/PMC5598257/ /pubmed/28962371 http://dx.doi.org/10.1016/j.toxrep.2015.01.009 Text en © 2015 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Domracheva, Ilona
Muhamadejev, Ruslan
Petrova, Marina
Liepinsh, Edvards
Gulbe, Anita
Shestakova, Irina
Duburs, Gunars
Arsenyan, Pavel
1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect
title 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect
title_full 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect
title_fullStr 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect
title_full_unstemmed 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect
title_short 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect
title_sort 1,2-dimyristoyl-sn-glycero-3-phosphocholine (dmpc) increases carmofur stability and in vitro antiproliferative effect
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598257/
https://www.ncbi.nlm.nih.gov/pubmed/28962371
http://dx.doi.org/10.1016/j.toxrep.2015.01.009
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