Upregulation of cyclin-dependent kinase inhibitors CDKN1B and CDKN1C in hepatocellular carcinoma-derived cells via goniothalamin-mediated protein stabilization and epigenetic modifications

Cell cycle deregulation is common in human hepatocellular carcinoma (HCC). To ensure proper cell cycle controlling, cyclin/cyclin-dependent kinases (CDK) complexes are tightly regulated by CDK inhibitors (CKIs) in normal cells. However, insufficient cyclin-dependent kinase inhibitor 1B (CDKN1B, also...

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Detalles Bibliográficos
Autores principales: Peng, Yu-Ting, Wu, Wen-Ren, Chen, Lih-Ren, Kuo, Kung-Kai, Tsai, Cheng-Hui, Huang, Yu-Ting, Lan, Yu-Hsuan, Chang, Fang-Rong, Wu, Yang-Chang, Shiue, Yow-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598353/
https://www.ncbi.nlm.nih.gov/pubmed/28962365
http://dx.doi.org/10.1016/j.toxrep.2015.01.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598353/
https://www.ncbi.nlm.nih.gov/pubmed/28962365
http://dx.doi.org/10.1016/j.toxrep.2015.01.010

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