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Gymnemasylvestre derived compounds inhibit GSH depletion and increase cGMP and nitric oxide to attenuate advanced glycation end products induced hypertrophic growth in renal tubular epithelial cells

The accumulation of advanced glycation end products (AGE) plays significant role in developing tubular hypertrophy during diabetic nephropathy (DN). Reactive oxygen species and nitric oxide (NO) are directly involved in the progression of DN. We have studied the effect of standardized Gymnemasylvest...

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Detalles Bibliográficos
Autores principales: Vidyashankar, Satyakumar, Babu, Uddagiri Venkanna, Patki, Pralhad Sadashiv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598397/
https://www.ncbi.nlm.nih.gov/pubmed/28962295
http://dx.doi.org/10.1016/j.toxrep.2014.08.015