A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions

All pharmaceutical companies are required to assess pharmacokinetic drug-drug interactions (DDIs) of new chemical entities (NCEs) and mathematical prediction helps to select the best NCE candidate with regard to adverse effects resulting from a DDI before any costly clinical studies. Most current mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Cherkaoui-Rbati, Mohammed H., Paine, Stuart W., Littlewood, Peter, Rauch, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598964/
https://www.ncbi.nlm.nih.gov/pubmed/28910306
http://dx.doi.org/10.1371/journal.pone.0183794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598964/
https://www.ncbi.nlm.nih.gov/pubmed/28910306
http://dx.doi.org/10.1371/journal.pone.0183794

Ejemplares similares