Concurrent treatment with simvastatin and NF-κB inhibitor in human castration-resistant prostate cancer cells exerts synergistic anti-cancer effects via control of the NF-κB/LIN28/let-7 miRNA signaling pathway

We examined the anti-cancer effects and molecular mechanism of simvastatin in human castration-resistant prostate cancer (CRPC) cells, particularly focused on LIN28B and its target molecule, let-7 microRNA (miRNA) among the various target genes of NF-κB. A human CRPC cell line (PC3) was used in the...

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Detalles Bibliográficos
Autores principales: Kang, Minyong, Lee, Kyoung-Hwa, Lee, Hye Sun, Jeong, Chang Wook, Ku, Ja Hyeon, Kim, Hyeon Hoe, Kwak, Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599006/
https://www.ncbi.nlm.nih.gov/pubmed/28910332
http://dx.doi.org/10.1371/journal.pone.0184644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599006/
https://www.ncbi.nlm.nih.gov/pubmed/28910332
http://dx.doi.org/10.1371/journal.pone.0184644

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