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Structure of the human transcobalamin beta domain in four distinct states

Vitamin B12 (cyanocobalamin, CNCbl) is an essential cofactor-precursor for two biochemical reactions in humans. When ingested, cobalamins (Cbl) are transported via a multistep transport system into the bloodstream, where the soluble protein transcobalamin (TC) binds Cbl and the complex is taken up i...

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Detalles Bibliográficos
Autores principales: Bloch, Joël S., Ruetz, Markus, Kräutler, Bernhard, Locher, Kaspar P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599065/
https://www.ncbi.nlm.nih.gov/pubmed/28910388
http://dx.doi.org/10.1371/journal.pone.0184932