Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks

Replicative helicases in all cell types are hexameric rings that unwind DNA by steric exclusion in which the helicase encircles the tracking strand only and excludes the other strand from the ring. This mode of translocation allows helicases to bypass blocks on the strand that is excluded from the c...

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Detalles Bibliográficos
Autores principales: Langston, Lance D, Mayle, Ryan, Schauer, Grant D, Yurieva, Olga, Zhang, Daniel, Yao, Nina Y, Georgescu, Roxana E, O'Donnell, Mike E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599239/
https://www.ncbi.nlm.nih.gov/pubmed/28869037
http://dx.doi.org/10.7554/eLife.29118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599239/
https://www.ncbi.nlm.nih.gov/pubmed/28869037
http://dx.doi.org/10.7554/eLife.29118

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