Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation

Amyloid β (Aβ) accumulation is an early event in the pathogenesis of Alzheimer’s disease (AD), leading to mitochondrial and synaptic dysfunction, tau accumulation, and eventual neuronal death. While the p53 apoptotic pathway has clearly been associated with Aβ deposits and neuronal apoptosis, the cr...

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Detalles Bibliográficos
Autores principales: Liu, Tian, Wang, Fang, LePochat, Patrick, Woo, Jung-A. A., Bukhari, Mohammed Zaheen, Hong, Kyung Woo, Trotter, Courtney, Kang, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599510/
https://www.ncbi.nlm.nih.gov/pubmed/28912445
http://dx.doi.org/10.1038/s41598-017-09996-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599510/
https://www.ncbi.nlm.nih.gov/pubmed/28912445
http://dx.doi.org/10.1038/s41598-017-09996-3

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