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The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca(2+) currents by altering calnexin-dependent trafficking of Ca(v)3.2 channels

Low-voltage-activated T-type calcium channels are essential contributors to the functioning of thalamocortical neurons by supporting burst-firing mode of action potentials. Enhanced T-type calcium conductance has been reported in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) and proposed...

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Detalles Bibliográficos
Autores principales: Proft, Juliane, Rzhepetskyy, Yuriy, Lazniewska, Joanna, Zhang, Fang-Xiong, Cain, Stuart M., Snutch, Terrance P., Zamponi, Gerald W., Weiss, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599688/
https://www.ncbi.nlm.nih.gov/pubmed/28912545
http://dx.doi.org/10.1038/s41598-017-11591-5