Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics

Tyrosine kinase inhibitors (TKIs) are highly potent cancer therapeutics that have been linked with serious cardiotoxicity, including left ventricular dysfunction, heart failure, and QT prolongation. TKI-induced cardiotoxicity is thought to result from interference with tyrosine kinase activity in ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Shim, Jaehee V., Chun, Bryan, van Hasselt, Johan G. C., Birtwistle, Marc R., Saucerman, Jeffrey J., Sobie, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599787/
https://www.ncbi.nlm.nih.gov/pubmed/28951721
http://dx.doi.org/10.3389/fphys.2017.00651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599787/
https://www.ncbi.nlm.nih.gov/pubmed/28951721
http://dx.doi.org/10.3389/fphys.2017.00651

Ejemplares similares