Cargando…

DNA Methylation Mediated Downregulation of miR-449c Controls Osteosarcoma Cell Cycle Progression by Directly Targeting Oncogene c-Myc

MicroRNAs (miRNAs) are critical regulators of gene expression, and they have broad roles in the pathogenesis of different diseases including cancer. Limited studies and expression profiles of miRNAs are available in human osteosarcoma cells. By applying a miRNA microarray analysis, we observed a num...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Qing, Li, Hua, Zhao, Xueling, Wang, Bing, Zhang, Lin, Zhang, Caiguo, Zhang, Fan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599909/ https://www.ncbi.nlm.nih.gov/pubmed/28924385 http://dx.doi.org/10.7150/ijbs.19476

Ejemplares similares

MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells
por: Mao, Aihong, et al.
Publicado: (2016)

TSP‐1 is downregulated and inversely correlates with miR‐449c expression in Cushing's disease
por: Ren, Jie, et al.
Publicado: (2019)

MiR-200c is a cMyc-activated miRNA that promotes nasopharyngeal carcinoma by downregulating PTEN
por: Chen, Pan, et al.
Publicado: (2016)

The Dynamics of miR-449a/c Expression during Uterine Cycles Are Associated with Endometrial Development
por: Naydenov, Mladen, et al.
Publicado: (2022)

The Mediation of miR-34a/miR-449c for Immune Cytokines in Acute Cold/Heat-Stressed Broiler Chicken
por: Li, Tao, et al.
Publicado: (2020)

Amplification of Both c‐myc and c‐raf‐1 Oncogenes in a Human Osteosarcoma
por: Ikeda, Shogo, et al.
Publicado: (1989)

Oligoasthenoteratozoospermia and Infertility in Mice Deficient for miR-34b/c and miR-449 Loci
por: Comazzetto, Stefano, et al.
Publicado: (2014)

MiR-449a attenuates autophagy of T-cell lymphoma cells by downregulating ATG4B expression
por: Zhang, Nan, et al.
Publicado: (2020)

MiR-29c regulates the expression of miR-34c and miR-449a by targeting DNA methyltransferase 3a and 3b in nasopharyngeal carcinoma
por: Niu, Man, et al.
Publicado: (2016)

miR-449a and CDK6 in gastric carcinoma
por: LI, LI-PING, et al.
Publicado: (2014)

Circadian miR-449c-5p regulates uterine Ca(2+) transport during eggshell calcification in chickens
por: Cui, Zhifu, et al.
Publicado: (2021)

MiR-25-3p Serves as an Oncogenic MicroRNA by Downregulating the Expression of Merlin in Osteosarcoma
por: Rao, Hua-chun, et al.
Publicado: (2020)

EGR1 promoted anticancer effects of Scutellarin via regulating LINC00857/miR‐150‐5p/c‐Myc in osteosarcoma
por: Han, Jian, et al.
Publicado: (2021)

mir-34b/c and mir-449a/b/c are required for spermatogenesis, but not for the first cleavage division in mice
por: Yuan, Shuiqiao, et al.
Publicado: (2015)

MiR-34a and miR-203 Inhibit Survivin Expression to Control Cell Proliferation and Survival in Human Osteosarcoma Cells
por: Chen, Xun, et al.
Publicado: (2016)

miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells
por: Noonan, Emily J., et al.
Publicado: (2010)

DNA Methylation Mediated Down-Regulation of miR-370 Regulates Cell Growth through Activation of the Wnt/β-Catenin Signaling Pathway in Human Osteosarcoma Cells
por: Zhang, Wentao, et al.
Publicado: (2017)

Control of multiciliogenesis by miR-34/449 in the male reproductive tract through enforcing cell cycle exit
por: Wu, Yu-Jie, et al.
Publicado: (2021)

HERG1 functions as an oncogene in pancreatic cancer and is downregulated by miR-96
por: Feng, Jin, et al.
Publicado: (2014)

miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1
por: Liu, Yonglei, et al.
Publicado: (2015)

MicroRNA-449b-5p Suppresses Proliferation, Migration, and Invasion of Osteosarcoma by Targeting c-Met
por: Li, Qian, et al.
Publicado: (2019)

Electro-acupuncture promotes the proliferation of neural stem cells and the survival of neurons by downregulating miR-449a in rat with spinal cord injury
por: Zhu, Yi, et al.
Publicado: (2017)

Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics
por: Chen, Bing-Jia, et al.
Publicado: (2014)

Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Proliferation and Metastasis of Osteosarcoma Cells by Targeting c-Met and SOX4 via miR-34a/c-5p and miR-449a/b
por: Sun, Zhenyu, et al.
Publicado: (2019)

Corrigendum to: MiR‐449a exerts tumor‐suppressive functions in human glioblastoma by targeting Myc‐associated zinc‐finger protein
Publicado: (2022)

MicroRNA-449a Is Downregulated in Non-Small Cell Lung Cancer and Inhibits Migration and Invasion by Targeting c-Met
por: Luo, Wenting, et al.
Publicado: (2013)

miR-193b exhibits mutual interaction with MYC, and suppresses growth and metastasis of osteosarcoma
por: Gao, Jinjian, et al.
Publicado: (2020)

Silencing circOMA1 Inhibits Osteosarcoma Progression by Sponging miR-1294 to Regulate c-Myc Expression
por: Shi, Yubo, et al.
Publicado: (2022)

BMP-2 and miR-29c in osteosarcoma tissues on proliferation and invasion of osteosarcoma cells
por: Chen, Xueqing, et al.
Publicado: (2019)

Oncogene addiction to c-MYC in myeloma cells
por: Holien, Toril, et al.
Publicado: (2012)

LncRNA PCED1B-AS1 knockdown inhibits osteosarcoma via methylation-mediated miR-10a downregulation
por: Wang, Bing, et al.
Publicado: (2022)

Investigating the inhibitory effect of miR-34a, miR-449a, miR-1827, and miR-106b on target genes including NOTCH1, c-Myc, and CCND1 in human T cell acute lymphoblastic leukemia clinical samples and cell line
por: Naderi, Tohid, et al.
Publicado: (2020)

miR-128-3p serves as an oncogenic microRNA in osteosarcoma cells by downregulating ZC3H12D
por: Zhu, Maoshu, et al.
Publicado: (2021)

MiR-449a regulates caprine endometrial stromal cell apoptosis and endometrial receptivity
por: An, Xiaopeng, et al.
Publicado: (2017)

miR-449a inhibits colorectal cancer progression by targeting SATB2
por: Sun, Xiaohua, et al.
Publicado: (2016)

miR-449a-5p suppresses CDK6 expression to inhibit cardiomyocyte proliferation
por: Li, Bing, et al.
Publicado: (2021)

Hsa-Mir-320c, Hsa-Mir-200c-3p, and Hsa-Mir-449c-5p as Potential Specific miRNA Biomarkers of COPD: A Pilot Study
por: Cerón-Pisa, Noemi, et al.
Publicado: (2022)

Increased miR-449a expression in colorectal carcinoma tissues is inversely correlated with serum carcinoembryonic antigen
por: CHEN, SHAOHUA, et al.
Publicado: (2014)

Circular RNA circ-NT5C2 acts as an oncogene in osteosarcoma proliferation and metastasis through targeting miR-448
por: Liu, Xunfa, et al.
Publicado: (2017)

Detection of the c-myc oncogene product in testicular cancer.
por: Sikora, K., et al.
Publicado: (1985)

Cannot write session to /tmp/vufind_sessions/sess_0u52b260k0uqtsuna680ke7b4u