Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery

Mutations in the gene encoding harmonin, a multi‐PDZ domain‐containing submembrane protein, cause Usher syndrome type 1 (congenital deafness and balance disorder, and early‐onset sight loss). The structure of the protein and biological activities of its three different classes of splice isoforms (a,...

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Detalles Bibliográficos
Autores principales: Bahloul, Amel, Pepermans, Elise, Raynal, Bertrand, Wolff, Nicolas, Cordier, Florence, England, Patrick, Nouaille, Sylvie, Baron, Bruno, El‐Amraoui, Aziz, Hardelin, Jean‐Pierre, Durand, Dominique, Petit, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599985/
https://www.ncbi.nlm.nih.gov/pubmed/28653419
http://dx.doi.org/10.1002/1873-3468.12729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599985/
https://www.ncbi.nlm.nih.gov/pubmed/28653419
http://dx.doi.org/10.1002/1873-3468.12729

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