Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody–peptide fusion

Product quality heterogeneities, such as a trisulfide bond (TSB) formation, can be influenced by multiple interacting process parameters. Identifying their root cause is a major challenge in biopharmaceutical production. To address this issue, this paper describes the novel application of advanced m...

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Detalles Bibliográficos
Autores principales: Goldrick, Stephen, Holmes, William, Bond, Nicholas J., Lewis, Gareth, Kuiper, Marcel, Turner, Richard, Farid, Suzanne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600124/
https://www.ncbi.nlm.nih.gov/pubmed/28500668
http://dx.doi.org/10.1002/bit.26339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600124/
https://www.ncbi.nlm.nih.gov/pubmed/28500668
http://dx.doi.org/10.1002/bit.26339

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