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Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody–peptide fusion
Product quality heterogeneities, such as a trisulfide bond (TSB) formation, can be influenced by multiple interacting process parameters. Identifying their root cause is a major challenge in biopharmaceutical production. To address this issue, this paper describes the novel application of advanced m...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600124/ https://www.ncbi.nlm.nih.gov/pubmed/28500668 http://dx.doi.org/10.1002/bit.26339 |