A novel SOD mimic with a redox-modulating mn (II) complex, ML1 attenuates high glucose-induced abnormalities in intracellular Ca(2+) transients and prevents cardiac cell death through restoration of mitochondrial function

A key contributor to the pathophysiology of diabetic cardiomyopathy, mitochondrial superoxide can be adequately countered by Mn-superoxide dismutase, which constitutes the first line of defense against mitochondrial oxidative stress. Our group has recently synthesized low molecular weight SOD mimics...

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Detalles Bibliográficos
Autores principales: Kain, Vasundhara, Sawant, Mithila A., Dasgupta, Aparajita, Jaiswal, Gaurav, Vyas, Alok, Padhye, Subhash, Sitasawad, Sandhya L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600348/
https://www.ncbi.nlm.nih.gov/pubmed/28955837
http://dx.doi.org/10.1016/j.bbrep.2016.01.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600348/
https://www.ncbi.nlm.nih.gov/pubmed/28955837
http://dx.doi.org/10.1016/j.bbrep.2016.01.003

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