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Inhibitory efficacy of bufadienolides on Na(+),K(+)-pump activity versus cell proliferation

Bufadienolides are cytotoxic drugs that may form the basis for anticancer agents. Due to structural and functional similarity to cardiotonic glycosides, application is restricted. We, therefore, investigated correlation of their putative anticancer effects with inhibition of Na(+),K(+)pumps. The nat...

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Detalles Bibliográficos
Autores principales: Xu, Yinfang, Liu, Xuan, Schwarz, Silvia, Hu, Lihong, Guo, Dean, Gu, Quanbao, Schwarz, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600443/
https://www.ncbi.nlm.nih.gov/pubmed/28955873
http://dx.doi.org/10.1016/j.bbrep.2016.03.015