A new lysine derived glyoxal inhibitor of trypsin, its properties and utilization for studying the stabilization of tetrahedral adducts by trypsin

New trypsin inhibitors Z-Lys-COCHO and Z-Lys-H have been synthesised. K(i) values for Z-Lys-COCHO, Z-Lys-COOH, Z-Lys-H and Z-Arg-COOH have been determined. The glyoxal group (–COCHO) of Z-Lys-COCHO increases binding ~300 fold compared to Z-Lys-H. The α-carboxylate of Z-Lys-COOH has no significant ef...

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Detalles Bibliográficos
Autores principales: Cleary, Jennifer A., Malthouse, J. Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600458/
https://www.ncbi.nlm.nih.gov/pubmed/28955834
http://dx.doi.org/10.1016/j.bbrep.2015.12.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600458/
https://www.ncbi.nlm.nih.gov/pubmed/28955834
http://dx.doi.org/10.1016/j.bbrep.2015.12.015

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